2019

Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis.

Yedida G., Milani M., Cohen GM. & Varadarajan S.  Cell Death and Disease, 10, 521, doi.org/10.1038/s41419-019-1759-y

 

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.

Milani M.Beckett AJ., Al-Zebeeby, A.Luo, X., Prior IA.Cohen GM. & Varadarajan S.  Cell Death Discovery, 5, 117, doi.org/10.1038/s41420-019-0199-x

THESIS:The complex regulatory mechanisms of the BCL-2 family of proteins in cancer.

Greaves G, April 2019.

 

2018

Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in haematological malignancies.

Al-Zebeeby A., Vogler M., Milani M., Richards C., Alotibi A., Greaves G., Dyer MJS., Cohen GM. & Varadarajan S.  Haematologica, doi:10.3324/haematol.2018.204701

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL.

Greaves G.Milani M.Butterworth M.Carter RJ.Byrne DP.Eyers PA.Luo X.Cohen GM. & Varadarajan S.  Cell Death and Differentiationdoi: 10.1038/s41418-018-0183-7

Selective BH3-mimetics targeting BCL-2, BCL-XL or MCL-1 induce severe mitochondrial perturbations. 

Henz, K.Al-Zebeeby, A.Basoglu, M., Fulda, S., Cohen, G. M., Varadarajan, S. Vogler, M.  Biological Chemistry, doi: 10.1515/hsz-2018-0233

2017

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis. 

Milani, M., Byrne, D. P., Greaves, G., Butterworth, M., Cohen, G. M., Eyers, P. A. & Varadarajan, S. Cell Death and Disease, 8, e2552. doi: 10.1038/cddis.2016.485

2016

BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells. 

Butterworth, M., Pettitt, A., Varadarajan, S. & Cohen, G. M. British Journal of Cancer, 114(6), 638-641. doi: 10.1038/bjc.2016.49

High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia.

Lucas, C. M., Milani, M., Butterworth, M., Carmell, N., Scott, L. J., Clark, R. E.,Cohen, G. M. & Varadarajan, S. Leukemia, 30(6), 1273-1281. doi: 10.1038/leu.2016.42

2015

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner. 

Varadarajan, S., Poornima, P., Milani, M., Gowda, K., Amin, S., Wang, H.-G. & Cohen, G. M. Oncotarget, 6(14), 12668-12681. doi:10.18632/oncotarget.3706

The transrepression arm of glucocorticoid receptor signaling is protective in mutant huntingtin-mediated neurodegeneration. 

Varadarajan, S., Breda, C., Smalley, J. L., Butterworth, M., Farrow, S. N., Giorgini, F. & Cohen, G. M. Cell Death and Differentiation, 22(8), 1388-1396. doi: 10.1038/cdd.2015.1

2013

Endoplasmic Reticulum Membrane Reorganization Is Regulated by Ionic Homeostasis. 

Varadarajan, S., Tanaka, K., Smalley, J. L., Bampton, E. T. W., Pellecchia, M., Dinsdale, D., Willars, G.B. & Cohen, G. M. PLOS One, 8(2). doi: 10.1371/journal.pone.0056603

Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis. 

Varadarajan, S., Butterworth, M., Wei, J., Pellecchia, M., Dinsdale, D. & Cohen, G. M. Neoplasia, 15(5), 568-578. doi:10.1593/neo.13230

The small molecule dispergo tubulates the endoplasmic reticulum and inhibits export. 

Lu, L., Hannoush, R. N., Goess, B. C., Varadarajan, S., Shair, M. D., & Kirchhausen, T. Molecular Biology of the Cell, 24(7), 1020-1029. doi:10.1091/mbc.E12-08-0575

2012

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. 

Varadarajan, S., Bampton, E. T. W., Smalley, J. L., Tanaka, K., Caves, R. E., Butterworth, M., Wei, J., Pellecchia, M., Mitcheson, J., Gant, T.W., Dinsdale, D. & Cohen, G. M. Cell Death and Differentiation, 19(12), 1896-1907. doi:10.1038/cdd.2012.108

2010

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1.

Son, J. K., Varadarajan, S., & Bratton, S. B. Cell Death and Differentiation, 17(8), 1288-1301. doi:10.1038/cdd.2010.9

2007

Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. 

Challa, M., Malladi, S., Pellock, B. J., Dresnek, D., Varadarajan, S., Yin, Y. W., White, K. & Bratton, S. B. The EMBO Journal, 26(13), 3144-3156. doi:10.1038/sj.emboj.7601745